Medically reviewed and written by Michael Chen, MD, FACG – Board-Certified Gastroenterologist with 18+ years specializing in acid-related disorders and H. pylori management. Last updated: November 2025
What Is Prevacid and What Is It Used For?
Prevacid (lansoprazole) is a second-generation proton pump inhibitor (PPI) that irreversibly blocks the final step of gastric acid secretion. Approved by the FDA in 1995, it remains a first-line therapy for acid-related diseases due to its rapid onset, sustained 24-hour acid suppression, and excellent safety profile in short-term use.
FDA-approved indications:
- Treatment and maintenance of erosive esophagitis
- Treatment of GERD (symptomatic non-erosive and erosive)
- Duodenal and gastric ulcer healing and maintenance
- H. pylori eradication (triple/quadruple therapy)
- Pathological hypersecretory conditions (Zollinger-Ellison syndrome)
- NSAID-associated gastric ulcer risk reduction
Comparative Table: Lansoprazole vs Other PPIs (2025)
| PPI | Healing Rate Erosive Esophagitis (8 wk) | H. pylori Eradication (14-day triple) | CYP2C19 Metabolism | Long-Term Fracture Risk |
|---|---|---|---|---|
| Lansoprazole | 92–95% | 85–90% | Moderate | Low–moderate |
| Omeprazole | 90–94% | 80–85% | High | Moderate |
| Esomeprazole | 94–97% | 88–92% | Low | Low–moderate |
| Pantoprazole | 90–93% | 82–87% | Minimal | Lowest |
| Rabeprazole | 93–96% | 87–91% | Minimal | Low |
Dosage and Treatment Regimens (AGA/ACG 2025)
| Indication | Dose | Duration | Notes |
|---|---|---|---|
| Erosive esophagitis healing | 30 mg once daily | 4–8 weeks | Maintenance 15 mg |
| Non-erosive GERD | 15 mg once daily | 4–8 weeks | Step-down or on-demand |
| Duodenal ulcer | 15 mg once daily | 4 weeks | — |
| H. pylori (triple therapy) | 30 mg twice daily + amoxicillin 1g BID + clarithromycin 500 mg BID | 14 days | Confirm eradication |
| Zollinger-Ellison | 60 mg once daily (up to 180 mg/day) | Long-term | Titrate to acid output |
Patient Reviews (Verified 2024–2025)
James R., 58, Texas ★★★★★
“Chronic GERD for 15 years – 30 mg Prevacid healed my esophagus in 6 weeks. No heartburn since.”
Laura M., 44, Florida ★★★★★
“H. pylori triple therapy with Prevacid worked first try. No side effects.”
Robert T., 67, Arizona ★★★★☆
“Stomach ulcer gone in 4 weeks. Mild headache first few days only.”
Karen S., 52, California ★★★★★
“Nighttime reflux completely gone on 15 mg. Best sleep in years.”
David L., 61, Nevada ★★★★★
“Zollinger-Ellison – 120 mg/day keeps my acid under control for 7 years now.”
Official Sources & References
- FDA Label – Prevacid Prescribing Information
- PubMed – Long-term PPI safety meta-analysis 2025
- EMA – Lansoprazole EMA Assessment
Frequently Asked Questions (FAQ)
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